Opportunity Information: Apply for PAS 18 188
The grant opportunity titled "Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional)" is a federal research funding program run by the National Institutes of Health (NIH) within the U.S. Department of Health and Human Services, specifically through the National Institute on Aging (NIA). It is designed to support small businesses that want to translate scientific ideas into practical, real-world products or services that could make a meaningful difference in the prevention, treatment, or care of people affected by Alzheimer's disease and related dementias. The program uses the Small Business Technology Transfer Research (STTR) mechanism, which generally means the applicant must be a small business working in formal collaboration with a nonprofit research institution such as a university or research hospital, with the goal of moving innovations out of the lab and closer to commercialization and real-world use.
This announcement uses the R41/R42 award structure, which is the typical two-phase STTR pathway. Phase I (R41) is usually meant to test early feasibility and demonstrate proof of concept, while Phase II (R42) supports more advanced research and development that builds on successful Phase I results. The "Clinical Trial Optional" wording signals that applicants are allowed, but not required, to propose clinical trial activities if those activities are appropriate for the technology being developed and if the project is ready for that stage. In practical terms, this makes the opportunity flexible: a company could propose preclinical validation work, development of a prototype, software development and testing, biomarker validation, or early-stage clinical evaluation, depending on what is scientifically justified and what would best accelerate the product or service toward use in the field.
The central purpose of the funding is to speed progress against Alzheimer's disease and Alzheimer's-disease-related dementias by encouraging innovation that can lead to deliverable tools. The FOA explicitly points toward projects that could help prevent disease onset, slow progression, improve diagnosis or monitoring, develop new therapies, and/or improve care for patients and support for caregivers. Because the emphasis is on "innovative products and/or services," the projects are expected to be more than basic science; they should be positioned as translational research and development efforts that could plausibly result in something deployable, such as a therapeutic candidate, diagnostic platform, digital health tool, device, laboratory assay, care model support technology, or other commercially relevant solution that addresses AD/ADRD needs.
Eligibility is limited to small businesses, reflecting the STTR program's focus on small-company innovation. The opportunity is categorized as a discretionary grant in the health funding area, with the associated CFDA number listed as 93.866. The announcement was created on November 28, 2017, and the original closing date was September 5, 2019. The listing indicates an expected number of awards of around 10, which suggests a competitive program with a limited number of funded projects. The award ceiling is shown as 0, which typically indicates that a single fixed cap is not provided in that summary field and that applicants should rely on the detailed FOA guidance and STTR budget rules for allowable funding levels by phase.
Overall, this funding opportunity is aimed at small businesses that have a strong research partnership and a credible development plan to move an Alzheimer’s or dementia-related innovation forward. Competitive applications would typically be expected to show clear significance to AD/ADRD, a technically sound development strategy suitable for an R41 or R42 stage, and a realistic pathway toward broader impact in healthcare, whether through commercialization, clinical adoption, or implementation in care settings.Apply for PAS 18 188
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on Nov 28, 2017.
- Applicants must submit their applications by Sep 05, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: Small businesses.
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Applicants also applied for:
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| Funding Opportunity |
|---|
| Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional) Apply for PAS 18 187 Funding Number: PAS 18 187 Agency: Department of Health and Human Services, National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Epicenters for the Prevention of Healthcare-Associated Infections (HAIs); Cycle II Multicenter Program Studies Apply for RFA CK 18 001 Funding Number: RFA CK 18 001 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $3,000,000 |
| Community-Based Coalition Enhancement Grants To Address Local Drug Crises Apply for SP 18 001 Funding Number: SP 18 001 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $50,000 |
| Determining and Monitoring Health Conditions Among US-Bound Refugees and Other Globally Mobile Populations Apply for RFA CK 18 003 Funding Number: RFA CK 18 003 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $700,000 |
| Clinical Trial Planning: Therapeutic/Indication Pairing Strategies (U34) (Clinical Trials Not Allowed) Apply for PAR 18 462 Funding Number: PAR 18 462 Agency: Department of Health and Human Services, National Institutes of Health Category: Health Funding Amount: $225,000 |
| Etiology and Outcome of Inflammatory Bowel Disease Apply for RFA DP 18 001 Funding Number: RFA DP 18 001 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $800,000 |
| Strengthening Care and Treatment Cascade Project Apply for 72052018RFA00002 Funding Number: 72052018RFA00002 Agency: Agency for International Development, Guatemala USAID-Guatemala City Category: Health Funding Amount: $15,000,000 |
| Advancing the South African HIV Response for Key Populations Apply for 72067418RFA00003 Funding Number: 72067418RFA00003 Agency: Agency for International Development, South Africa USAID-Pretoria Category: Health Funding Amount: $35,000,000 |
| Supplement: Improving Quality of Care and Health Impact through Innovative System Technologies in Malawi under PEPFAR Apply for CDC RFA GH12 12500501SUPP17 Funding Number: CDC RFA GH12 12500501SUPP17 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: $2,620,080 |
| Understanding and Addressing the Disparity in Vaccination Coverage Among U.S. Adolescents Living in Rural Versus Urban Areas Apply for RFA IP 18 003 Funding Number: RFA IP 18 003 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $350,000 |
| Implementation of Evidence-Informed Behavioral Health Models to Improve HIV Health Outcomes for Black Men who Have Sex with Men – Evaluation and Technical Assistance Provider Apply for HRSA 18 053 Funding Number: HRSA 18 053 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Bright Futures Pediatric Implementation Program Apply for HRSA 18 078 Funding Number: HRSA 18 078 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Implementation of Evidence-Informed Behavioral Health Models to Improve HIV Health Outcomes for Black Men Who Have Sex with Men - Demonstration Sites Apply for HRSA 18 047 Funding Number: HRSA 18 047 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Ryan White HIV/AIDS Program Part D -- Women, Infants, Children, and Youth (WICY) Grants Supplemental Funding Apply for HRSA 18 044 Funding Number: HRSA 18 044 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Ryan White HIV/AIDS Program Part C Capacity Development Program Apply for HRSA 18 051 Funding Number: HRSA 18 051 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Planning Grant to Develop Phase III Clinical Trials for Lewy Body Dementia (R34 clinical Trial Not Allowed) Apply for RFA NS 18 017 Funding Number: RFA NS 18 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Health Funding Amount: $150,000 |
| Networking, Certifying, and Training Suicide Prevention Hotlines and Disaster Distress Helpline (Lifeline/DDH) Apply for SM 18 001 Funding Number: SM 18 001 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $6,130,000 |
| Economic Studies of Immunization Policies and Practices Apply for RFA IP 18 002 Funding Number: RFA IP 18 002 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $300,000 |
| Promoting Research in Basic Neuroscience (R01) Apply for PAS 18 483 Funding Number: PAS 18 483 Agency: Department of Health and Human Services, National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Historically Black Colleges and Universities Apply for TI 18 005 Funding Number: TI 18 005 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $500,000 |
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