Opportunity Information: Apply for PA 17 091
The Fertility Status as a Marker for Overall Health (R01) grant opportunity (PA-17-091) is a National Institutes of Health (NIH) funding announcement that supports research testing the idea that a persons fertility status can serve as a meaningful indicator of their broader health. The premise behind the program is that while it is already well established that many chronic diseases and exposures can reduce fertility (for example, cancer treatments, diabetes, and obesity), the reverse relationship has not been studied as thoroughly: whether infertility, subfertility, or other measurable aspects of fertility function can signal underlying health risks, shared biological pathways, or future disease. The FOA highlights growing evidence that infertility is often not an isolated problem limited to the reproductive system, but may be physiologically and/or genetically connected to other conditions, and that epidemiologic studies have identified associations between fertility status in both males and females and various non-reproductive (somatic) diseases and disorders. In short, the program treats fertility as a potential "window" into overall health, and encourages research designed to validate, explain, and use that window.
A key boundary of this funding opportunity is scope: it is focused on studies that evaluate fertility as a marker or indicator of overall health. That means the primary direction of inference should run from fertility status to broader health outcomes, risk profiling, shared mechanisms, or prediction of disease, rather than from disease to fertility impairment. Applications that mainly examine how a particular disease or disorder affects fertility are explicitly described as outside the scope of this program. In practice, competitive projects would be expected to frame fertility-related measures (such as infertility diagnoses, time-to-pregnancy, semen parameters, ovulatory function, ovarian reserve markers, or reproductive lifespan indicators, depending on the research question) as an exposure, predictor, or stratification variable for understanding general health trajectories, comorbidities, or long-term outcomes, rather than as the outcome being damaged by another condition.
The mechanism is an NIH R01, meaning it is intended for substantial, hypothesis-driven research projects that can support multi-year, well-developed studies. The opportunity falls under the Health, Income Security and Social Services activity category and is associated with CFDA number 93.865. The original posting date in the source information is 2016-12-19, and the listed original closing date is 2020-05-07, indicating the historical window for that particular posting (applicants typically need to confirm current availability or reissued announcements when planning a submission).
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities. The FOA also explicitly calls out additional eligible applicant groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, tribal governments other than federally recognized entities, and foreign (non-U.S.) organizations. This wide eligibility reflects NIHs interest in encouraging diverse institutions and research settings to investigate how fertility-related signals might inform broader health understanding across populations.
Overall, this opportunity is aimed at strengthening the scientific foundation for treating fertility status not only as a reproductive health endpoint, but also as a clinically and biologically informative marker tied to general health, disease risk, and underlying systemic pathways. The most responsive proposals would be those that clearly keep fertility status at the center as the marker or predictor and build rigorous designs to connect fertility-related measures to wider health outcomes, mechanisms, or long-term risk patterns in males, females, or both.Apply for PA 17 091
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Fertility Status as a Marker for Overall Health (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on 2016-12-19.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Funding Opportunity |
|---|
| Fertility Status as a Marker for Overall Health (R21) Apply for PA 17 092 Funding Number: PA 17 092 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Zika Virus (ZIKV) Complications (R21) Apply for PA 17 085 Funding Number: PA 17 085 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| NCMRR Early Career Research Award (R03) Apply for PAR 17 161 Funding Number: PAR 17 161 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $100,000 |
| Interaction of HIV and Neurodevelopment of Children in Resource-Limited Settings: Improving Assessments (R01) Apply for RFA HD 18 019 Funding Number: RFA HD 18 019 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Interaction of HIV and Neurodevelopment of Children in Resource-Limited Settings: Improving Assessments (R21) Apply for RFA HD 18 020 Funding Number: RFA HD 18 020 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Biomarkers: Bridging Pediatric and Adult Therapeutics (R21) Apply for PAR 17 169 Funding Number: PAR 17 169 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| NICHD Research Education Programs (R25) Apply for PAR 17 183 Funding Number: PAR 17 183 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $150,000 |
| Translational Research in Pediatric and Obstetric Pharmacology and Therapeutics (R21) Apply for PAR 17 187 Funding Number: PAR 17 187 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Translational Research in Pediatric and Obstetric Pharmacology and Therapeutics (R01) Apply for PAR 17 189 Funding Number: PAR 17 189 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Translational Research in Pediatric and Obstetric Pharmacology and Therapeutics (R03) Apply for PAR 17 188 Funding Number: PAR 17 188 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Human-Animal Interaction (HAI) Research (R21) Apply for PAR 17 229 Funding Number: PAR 17 229 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Resource-Related Research Projects in the Epidemiology and Prevention of Pediatric Injury (R24) Apply for PAR 17 228 Funding Number: PAR 17 228 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $375,000 |
| Human-Animal Interaction (HAI) Research (R03) Apply for PAR 17 230 Funding Number: PAR 17 230 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Human-Animal Interaction (HAI) Research (R01) Apply for PAR 17 231 Funding Number: PAR 17 231 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $499,999 |
| Development of Appropriate Pediatric Formulations and Pediatric Drug Delivery Systems (R03) Apply for PAR 17 191 Funding Number: PAR 17 191 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Development of Appropriate Pediatric Formulations and Pediatric Drug Delivery Systems (R21) Apply for PAR 17 192 Funding Number: PAR 17 192 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Development of Appropriate Pediatric Formulations and Pediatric Drug Delivery Systems (R01) Apply for PAR 17 193 Funding Number: PAR 17 193 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Development of Appropriate Pediatric Formulations and Pediatric Drug Delivery Systems (R43) Apply for PAR 17 199 Funding Number: PAR 17 199 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Development of Appropriate Pediatric Formulations and Pediatric Drug Delivery Systems (R41) Apply for PAR 17 200 Funding Number: PAR 17 200 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Identification of Reproductive-Tract Specific Proteins/Transcripts for the Development of Male and Female Non-Hormonal Contraceptives (R01) Apply for RFA HD 18 002 Funding Number: RFA HD 18 002 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
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