Opportunity Information: Apply for RFA RM 19 005
The NIH Directors Pioneer Award Program (DP1 Clinical Trial Optional), funding opportunity number RFA-RM-19-005, is a competitive NIH grant designed to back individual researchers who show exceptional creativity and who are willing to pursue ideas that are genuinely bold. The central purpose is to fund highly innovative, potentially transformative research that could meaningfully advance human health. It sits within the NIH Common Fund High-Risk, High-Reward Research program, which is specifically meant to support ambitious projects that may not fit neatly into conventional funding mechanisms but could produce outsized scientific gains if successful.
A key point of this opportunity is what NIH means by "pioneering." The research is expected to move in a substantially different scientific direction than what the applicant is already doing in their existing research program, and it should also stand apart from what is already being widely pursued by others. In other words, this is not intended for incremental next-step studies. It is meant for applicants who can make a convincing case that their approach, concept, or direction is unusually original, and that it has a real chance to shift thinking or open new frontiers in a way that ultimately benefits health.
The topic scope is intentionally broad. NIH welcomes applications across areas tied to its mission, including behavioral science, social science, biomedical science, applied science, and formal sciences. Projects may be basic, translational, or clinical in nature, and the notice indicates that clinical trials are optional under this DP1 announcement. This flexibility allows applicants to propose anything from foundational discovery work to research closer to patient impact, as long as the proposal clearly reflects the kind of unconventional, high-impact trajectory the Pioneer Award is meant to support.
Eligibility is also broad and spans many organization types. Eligible applicants include various levels of government (state, county, city or township, and special districts), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3), other than higher education institutions), for-profit organizations other than small businesses, and small businesses. It also includes Native American tribal governments (federally recognized), Native American tribal organizations (other than federally recognized tribal governments), and public housing authorities/Indian housing authorities, along with other entities as further clarified in the funding announcement. The program also explicitly encourages participation from individuals with diverse backgrounds, signaling NIH interest in broadening the pool of innovators and perspectives represented among awardees.
From an administrative standpoint, this is a discretionary grant opportunity administered by the U.S. Department of Health and Human Services through the National Institutes of Health. The funding activity category is health and the CFDA listing provided is 93.310. For the specific cycle described in the source data, the opportunity was created on April 3, 2019, with an original closing date of September 9, 2019. NIH anticipated making about 7 awards, and the listed award ceiling is $700,000, indicating a strong level of support per project relative to many traditional grant mechanisms, consistent with the program's goal of enabling investigators to take substantial scientific risks.
Overall, this opportunity is best understood as NIH's attempt to identify and empower unusually creative scientists to pursue ideas that are hard to fund through standard channels, but that could reshape a field or create entirely new lines of inquiry. The emphasis is less on producing guaranteed, predictable outcomes and more on backing the kind of visionary research direction that, if it works, could have an outsized effect on science and human health.Apply for RFA RM 19 005
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "NIH Directors Pioneer Award Program (DP1 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on Apr 03, 2019.
- Applicants must submit their applications by Sep 09, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $700,000.00 in funding.
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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